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Messages - quadz

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2
Jokes / Re: Funny Pictures
« on: Today at 03:13:57 PM »


3
Politics / Re: Current Politics & History Only Thread
« on: April 05, 2020, 07:55:15 PM »
There is a HUGE difference between chloroquine phosphate and hydroxychloroquine sulfate

Interestingly this was published on March 18, just one day before Trump's press conference:

https://www.nature.com/articles/s41421-020-0156-0

Quote from: Liu, J., Cao, R., Xu, M. et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov 6, 16 (2020)
We have recently reported that two drugs, remdesivir (GS-5734) and chloroquine (CQ) phosphate, efficiently inhibited SARS-CoV-2 infection in vitro1. Remdesivir is a nucleoside analog prodrug developed by Gilead Sciences (USA). A recent case report showed that treatment with remdesivir improved the clinical condition of the first patient infected by SARS-CoV-2 in the United States2, and a phase III clinical trial of remdesivir against SARS-CoV-2 was launched in Wuhan on February 4, 2020. However, as an experimental drug, remdesivir is not expected to be largely available for treating a very large number of patients in a timely manner. Therefore, of the two potential drugs, CQ appears to be the drug of choice for large-scale use due to its availability, proven safety record, and a relatively low cost.
[...]
CQ (N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine) has long been used to treat malaria and amebiasis. However, Plasmodium falciparum developed widespread resistance to it, and with the development of new antimalarials, it has become a choice for the prophylaxis of malaria. In addition, an overdose of CQ can cause acute poisoning and death3. In the past years, due to infrequent utilization of CQ in clinical practice, its production and market supply was greatly reduced, at least in China. Hydroxychloroquine (HCQ) sulfate, a derivative of CQ, was first synthesized in 1946 by introducing a hydroxyl group into CQ and was demonstrated to be much less (~40%) toxic than CQ in animals4. More importantly, HCQ is still widely available to treat autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. Since CQ and HCQ share similar chemical structures and mechanisms of acting as a weak base and immunomodulator, it is easy to conjure up the idea that HCQ may be a potent candidate to treat infection by SARS-CoV-2. Actually, as of February 23, 2020, seven clinical trial registries were found in Chinese Clinical Trial Registry (http://www.chictr.org.cn) for using HCQ to treat COVID-19. Whether HCQ is as efficacious as CQ in treating SARS-CoV-2 infection still lacks the experimental evidence.

To this end, we evaluated the antiviral effect of HCQ against SARS-CoV-2 infection in comparison to CQ in vitro.

(Not sure how long it may have been on Trump's radar before that. I'd been seeing rumblings about its use since sometime in February, I believe.)


and if Trump can’t explain that difference he is not qualified to talk on the subject. You can kill yourself with both. If you don’t know the difference yourself then you are not qualified to prescribe it for anyone but if you want to take Trump’s advice and “do what you want” then by all means, kill yourself. MAGA.

OK, but in Trump's March 19 press conference, he stated (twice) that the drug would be made available by prescription, and that "doctors will handle it."

So it seems inaccurate to characterize his advice as "do what you want."

That said, a few sentences earlier in his rambling, Trump had communicated very poorly the idea that the drug could be safely prescribed in a SARS-CoV-2 context since its risks were already understood:

"But it is known as a malaria drug, and it’s been around for a long time and it’s very powerful. But the nice part is, it’s been around for a long time, so we know that if it — if things don’t go as planned, it’s not going to kill anybody. When you go with a brand-new drug, you don’t know that that’s going to happen."

I think what he's saying can be understood in context - but I'd agree it's irresponsibly poorly phrased.

4
Politics / Re: Current Politics & History Only Thread
« on: April 05, 2020, 05:52:23 PM »

https://twitter.com/USPoliticsPoll/status/1246264747118530562

Looking rough for Biden - but heck, might vote for this guy myself. ;)




5
/dev/random / Re: The Strange and Interesting Thread
« on: April 05, 2020, 01:17:41 PM »

https://twitter.com/historylvrsclub/status/1246613035252408322

Alcohol, cannabis, chloroform, and morphine - skillfully combined, of course.


6
Politics / Re: Novel Coronavirus (COVID-19) Thread
« on: April 05, 2020, 12:57:33 PM »
Interesting choice of prophylactic


https://twitter.com/yashar/status/1246816324363276295


7
Politics / Re: Novel Coronavirus (COVID-19) Thread
« on: April 03, 2020, 09:34:55 PM »
Oof. Wife sent me this. Apparently this Detroit bus driver fell ill about 4 days after posting this video about being coughed on, and died today.

https://www.npr.org/sections/coronavirus-live-updates/2020/04/03/826817866/take-this-serious-bus-driver-dies-of-covid-19-after-calling-out-coughing-rider


https://www.facebook.com/1242205136/videos/10222496193013898/


(If not for WHO and CDC bullshitting about "masks don't help", people in these circumstances might still be alive.)

8
Quake / Re: Focalor's Quake1 Pak for Quake2
« on: April 03, 2020, 08:04:49 PM »
Discovered that apparently Quake2 doesn't actually use the hyperblaster spin-up sound file.

Interesting. I'm unfamiliar with Q2 sound logic; but I notice CHAINGUN has several states, while HYPERBLASTER (and most other weapons) have just one:

https://github.com/tastyspleen/r1q2-archive/blob/master/client/cl_fx.c#L311 (chaingun 1,2,3)

https://github.com/tastyspleen/r1q2-archive/blob/master/client/cl_fx.c#L293 (hyperblaster)



9
Politics / Re: Current Politics & History Only Thread
« on: April 03, 2020, 06:47:48 PM »
And look at that silly video in that tweet you shared, complete with the patriotic imagery, inspirational/emotional music score behind it - give me a break.

OK, you're half way there.

There was cognition that interpreted that clip as a "silly video" and produced the emotional response "give me a break."

Call that up again. I agree it's a reasonable response to that sort of production.

Now turn that attention to the Pakman video - will similar alarm bells go up?



P.S. what's wrong with patriotic imagery? Why do you hate America. ;)



10
Politics / Re: Novel Coronavirus (COVID-19) Thread
« on: April 03, 2020, 02:45:46 PM »

11
Politics / Re: Novel Coronavirus (COVID-19) Thread
« on: April 03, 2020, 09:28:18 AM »
Hope this potential vaccine bears out in human trials:

https://nypost.com/2020/04/02/scientists-believe-they-found-potential-coronavirus-vaccine/

Interesting that it might be able to be distributed in patch form.



12
Jokes / Re: Funny Pictures
« on: April 02, 2020, 01:43:11 PM »

13
Politics / Re: Novel Coronavirus (COVID-19) Thread
« on: April 02, 2020, 01:01:27 PM »
Assuming this is accurate, things are looking rough in Ecuador


https://twitter.com/RealYeyoZa/status/1245489478019485701


...OK there seems to be pushback on parts of the video (e.g. the body bags footage at the end has been used in several videos - Spain, etc.)

Nonetheless the gist of it is backed up by other reporting:

https://www.ecuadortimes.net/there-are-450-bodies-to-be-collected-in-guayaquil-and-lenin-moreno-offers-a-decent-burial/

https://www.miamiherald.com/news/nation-world/world/americas/article241716021.html


14
Politics / Re: Novel Coronavirus (COVID-19) Thread
« on: April 02, 2020, 12:24:43 PM »
"Georgia governor says he didn’t know asymptomatic people can spread coronavirus"

https://www.macon.com/news/coronavirus/article241712446.html

Quote
Kemp said he was “finding out that this virus is now transmitting before people see signs.”

“Those individuals could have been infecting people before they ever felt bad, but we didn’t know that until the last 24 hours,” he said. He added that the state’s top doctor told him that “this is a game-changer.”

Jesus man, we've known this since January.

:WTF:

15
Politics / Re: Novel Coronavirus (COVID-19) Thread
« on: April 02, 2020, 12:21:58 PM »
A while ago you said something like you didn't think China would intentionally release something like this into the wild because the rewards for them wouldn't be worth the cost, or something like that.
[...]
You still think China is as much of an unwitting victim in all this as everyone else?

It doesn't make sense to me that China would deliberately release a virus like this into their own cities.

If it were a deliberate op, I'd expect them to send an asymptomatic carrier elsewhere in the world to start the spread, meanwhile reacting with (pre-planned) measures to prevent it from entering China as soon as the news breaks. Something along those lines.

So no, I'd be very surprised if it began intentionally.

However, the part that makes total sense to me is that China obfuscated and downplayed the nature of the virus, allowing it to spread to numerous countries in December / January while the CCP was still claiming "no known human-to-human transmission", "no need for travel restrictions", etc.

I hope they're held to account for their behavior, in some way, by - well basically the rest of the planet.

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